MAPK8 and familial pancreatic carcinoma: In addition, western blot results showed that CCTDD NPs significantly increased the protein expression of p-JNK, p-ERK, and p-P38, while the protein expression of JNK, ERK, and P38 was basically unchanged, indicating that CCTDD NPs can regulate the MAPK pathway to achieve the effect of treating pancreatic cancer cells.