Based on the described seminal work on the role of ABC and SLC transporters in CIPN, the importance of nucleoside transporters for NRTIs, and the established association between NRTIs and ATN, we hypothesize that nucleoside transporters play a pivotal role in the accumulation of NRTIs within the PNS and the associated ATN phenotype. This evidence concerns the gene ABCB6 and oculocutaneous albinism type 1.