To further substantiate the induction of apoptosis and/or necrosis and to explore the antitumor effects of CEC@ZIF-8 NPs, we conducted Annexin V-FITC/PI dual fluorescence staining on HeLa, SiHa, and TC-1 cancer cells treated with ZIF-8 NPs, free CEC, or CEC@ZIF-8 NPs for 24 h using flow cytometry (Figure 5c,d and Figure S7a–d). The gene discussed is ANXA5; the disease is cancer.