CYP3A4 and pulmonary arterial hypertension: The effects of LMN, POH, PAH, and PA on nine CYP isoforms (CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, and CYP3A4) were evaluated in pooled HLMs (Table 1 and Figure 1).