TNF and Skin ulcer: The anti-inflammatory activity observed at low doses of ozone is due to an increase in the cell cycle mediated by the synthesis of growth factors and the activation of the NF-κB factor, which triggers transcription of the genes of pro-inflammatory molecules, such as interleukin 8 (IL-8) and tumor necrosis factor α (TNF-α) and TGF-β [11] in infections, allergic dermatitis, skin ulcers, psoriasis, and fibromyalgia.