CD4 and colitis: Oral treatment with CNP-miR146a in adoptively transferred colitis Rag2−/− mice significantly reduced the expansion of colonic lamina propria (cLP) Th1 cell population, defined as CD4+Tbet+IFNg+ cells from approximately 30% in PBS-treated mice to approximately 13% in CNP-miR146a-treated mice (p < 0.05; Figure 6A).