CD4 and colitis: Thus, this study was designed to test the effects of orally-delivered CNP-miR146a in Rag2−/− mice with adoptive CD4+CD45RBHI T cell transfer colitis, a model developed by Powrie et al. [33], which requires both spontaneous proliferation of T cells driven by microbiota-derived innate signals and antigen-specific T cell proliferation [34].