Recent studies showed that EVs derived from microglia and neurons deliver miR-124 to astrocytes, leading to the upregulation of astrocytic glutamate transporter-1 (GLT-1) expression, which enhances the clearance of extracellular glutamate in normal conditions and in glioma (Figure 1A) [67,68]. This evidence concerns the gene SLC1A2 and central nervous system cancer.