first: application of imiquimod cream on depilated skin at 4 cm × 6 cm to cause psoriasis in micethrough the transdermal medication of PEO, a significant improvement in psoriasis symptoms was observed in mice. For instance, reduction in pruritus and erythema levels, improvement in skin elasticity and melanin levels, and more body weight gain coexisted with lower serum levels of IL-10 and TGF-βhistopathological analysis with H&E staining showed that PEO decreased histopathological features of psoriasis in mice. This evidence concerns the gene IL10 and Erythema.