Tetracycline may interfere with the function of key molecules in this pathway, affecting the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) or the phosphorylation and activation of Akt protein, thereby disrupting the metabolism of pancreatic cells, altering the sensitivity of pancreatic cells to apoptotic signals, promoting cell damage and inflammatory responses [42], and ultimately inducing acute pancreatitis. The gene discussed is AKT1; the disease is acute pancreatitis.