Tetracycline may abnormally activate this pathway under aerobic conditions through specific regulatory mechanisms, causing a stable accumulation of the hypoxia-inducible factor-1α (HIF-1α) protein, which initiates the transcription of inflammation-related genes, promotes the infiltration of inflammatory cells and the release of inflammatory factors, and affects the energy metabolism of pancreatic cells, triggering inflammation and damage [45] and thereby inducing acute pancreatitis. This evidence concerns the gene HIF1A and acute pancreatitis.