The top three pathways related to Ccl2 were fluid shear stress and atherosclerosis (mmu05418), lipid and atherosclerosis (mmu05417), NOD-like receptor signaling pathway (mmu04621) and the top three pathways associated with Esr1 were chemical carcinogenesis-receptor activation (mmu05207), thyroid hormone signaling pathway (mmu04919) and proteoglycans in cancer (mmu05205). Here, ESR1 is linked to cancer.