Moreover, Jing Cai et al. [3] found that TP induces pyroptosis in head and neck cancers by inhibiting mitochondrial hexokinase II expression, which promotes the translocation of Bcl-xL/Bcl-2-associated death promoter (Bad) and Bcl-2-associated-X-protein (Bax), and the activation of caspase-3, which then cleaves and activates gasdermin E (GSDME). Here, GSDME is linked to head and neck cancer.