The LMW PAH binary mixtures (1-MeA + Flthn) without B[a]P also altered inflammatory pathways with increases observed in pro-inflammatory bioactive lipid pathways, such as cytosolic phospholipase A2 (cPLA2), cyclooxygenase (COX2), and downstream prostaglandins (PGE2, PGD2), isoprostanes, and pro-inflammatory cytokines, such as keratinocyte-derived chemokine (KC), IL6, TNF, and IL1B, among others. Here, PLA2G4A is linked to pulmonary arterial hypertension.