Although ETs do not regulate cell steatosis but cause inflammation in HepaRG and HCC cells, here, we further investigated the effect of ETs (single exposure and in combination) on the expression of cell fibrosis markers such as AST, FGF-23, Cyt-7, p21, TGF-β, TIMP2, and MMP2. The gene discussed is MMP2; the disease is hepatocellular carcinoma.