TIMP2 and liver disorder: Acute exposure of 2-ET, 3-ET, and 4-ET, one or in combination, and chronic 2-ET exposure upregulated cell fibrosis markers such as AST, FGF-23, Cyt-7 p21, TGFβ, TIMP2, and MMP2 in liver cell models, suggesting that ETs target liver cells (Figure 6C) and may dysregulate liver function and increase risk of liver diseases such as NAFLD.