Our data demonstrated that exposure to 2-ET or in a combination of 3-ET and 4-ET increased FGF-23, Cyt-7, and TGF-β in HepaRG cells, and exposure to 2-ET, 3-ET, and 4-ET increased p21, MMP2, and TGF-β in HCC HepG2 cells. The gene discussed is TGFB1; the disease is hepatocellular carcinoma.