The Correction of Hemoglobin Outcomes in Renal Insufficiency (CHOIR) trial demonstrated that aiming for a target Hb concentration of 13.5 g/dL was related to an elevated combined risk of death, myocardial infarction, stroke, and hospitalization due to congestive heart failure while not yielding any enhancement in life quality [9]. The gene discussed is GSTM1; the disease is Stroke.