To elucidate the molecular mechanisms by which MPs aggravate synovial cell infection and pyroptosis in SLE mice, we analyzed the expression levels of NRF2, KEAP1, P65, p-P65, HO-1, IκBα, and p-IκBα to assess the NF-κB signaling pathway and oxidative stress in the synovium. This evidence concerns the gene HMOX1 and systemic lupus erythematosus.