The functional annotation of the differential genes showed that the differential genes related to PER3 were enriched in GBM tissues for biological processes such as humoral immune response, phagocytosis, and complement activation, cellular components such as immunoglobulin complexes, blood microparticles, and outer plasma membrane, as well as for molecular functions such as antigen binding, immunoglobulin receptor binding, receptor ligand activity, and signaling receptor activation. The gene discussed is PER3; the disease is glioblastoma.