Previously, we demonstrated that extracts of Salvia plebeia, Oenothera biennis, and Korean red ginseng inhibit the binding of PD-1 to PD-L1, thereby showing significant anti-cancer effects in humanized PD-1/PD-L1 knock-in mouse models of colorectal cancer [29,30,31]. The gene discussed is CD274; the disease is colorectal cancer.