Reduced signs associated with cognitive behavior; improvement in genes related to Alzheimer’s disease and memory; regulated of inflammatory response via microglia/macrophage polarization; ameliorated oxidative stress via Nrf2-HO-1 signaling pathway; improved cognitive impairments (new object recognition, object location, passive avoidance tests). The gene discussed is HMOX1; the disease is early-onset autosomal dominant Alzheimer disease.