Interestingly, in the mice with high-grade colitis, NPS 2143 had no effect on COX2 expression but instead increased the expression of the PGE2-degrading enzyme 15-hydroxyprostaglandin dehydrogenase (15-PGDH), which is a physiological antagonist of COX2 [15,37]. The gene discussed is HPGD; the disease is colitis.