MLH1 and colorectal carcinoma: Likewise, a retrospective analysis of data from participants in the National Cancer Institute Colon Cancer Family Registry also found a significantly increased hazard ratio of CRC with increased BMI for MLH1 mutation carriers (HR: 1.36; 95% CI: 1.04 to 1.77) but not for those with mutation in MSH2, MSH6, or PMS2 [5].