CCL2 and Anxiety: Indeed, PEA treatment in a model of obese mice induced by a high-fat diet resulted in improved anxiety-like behaviors and a reduction in systemic inflammation by lowering serum levels of pro-inflammatory mediators such as TNF-α, interleukin-1 β (IL-1β), Monocyte Chemoattractant Protein-1 (MCP-1), and lipopolysaccharide (LPS).