IGF1R and melanoma: For WM266-4 melanoma cells, results showed up-regulation of pro-apoptotic BAD, BAX, BID, CASP3, CASP9, FADD, FAS, and TP53, and down-regulation of APAF1 and CYCS. Pro-survival genes, including AKT1, BCL-2, HRAS, IGF1, IGF1R, KRAS, NRAS, MYC, and genes from the YWHA family, showed a reduction in their mRNA levels after NC treatment.