For WM-115 primary melanoma cells, results showed up-regulation of many pro-apoptotic genes, including APAF1, BAD, BAX, BID, CASP3, CASP8, CASP9, CYCS, FADD, and down-regulation of pro-survival genes BCL-2, HRAS, IGF1, KRAS, MYC, and YWHA family. The gene discussed is CASP8; the disease is melanoma.