DNMT1 and breast carcinoma: Furthermore, both substances are involved in epigenetic regulation: resveratrol reduces DNA methyltransferase (DNMT) activity and their mRNA levels in breast cancer cells, leading to changes in DNA methylation, and may modulate histone deacetylase (HDAC) activity [111], while EVOO could affect miRNA expression, inhibiting DNMT activity and expression [112].