Furthermore, the kinetics of SEMA were related to sepsis complications; SEMA3A, SEMA3C, SEMA3F, and SEMA4D were related to respiratory failure; SEMA3C and SEMA7A were related to acute kidney injury, while SEMA3C and SEMA3F were related to septic shock. The gene discussed is SEMA4D; the disease is acute kidney injury.