Changes in ACE2 function following SARS-CoV-2 infection could affect more individuals with previous altered ACE2 expression caused by obesity, diabetes or hypertension [5], and it is very important to highlight that these comorbidities, together with old age, male sex, and racial/ethnic disparities have been associated with the development of severe COVID-19 [6]. Here, ACE2 is linked to obesity due to melanocortin 4 receptor deficiency.