Although our study is not trying to associate the SARS-CoV-2 infection and COVID-19 development with ACE2 variants, it would have been relevant to evaluate how the presence of comorbidities could affect the association of ACE2 variants with the persistence of RT–qPCR positivity for SARS-CoV-2, but the lack of comorbidities data of the study population did not allow it. Here, ACE2 is linked to COVID-19.