In microbial infections, SIRT1 is known to be involved in host defense and helps in regulating innate and inflammatory responses, such as in the case of tuberculosis patients and in the pathogenesis of COVID-19, where a low level of the protein correlates with increased levels of proinflammatory cytokines; therefore, this protein is being targeted for interventions in acute and chronic infectious diseases [20]. This evidence concerns the gene SIRT1 and tuberculosis.