SIRT1 and brucellosis: Nevertheless, we previously reported the potential beneficial effects of SIRT1 activators, such as piceatannol and ginsenoside Rg3, as an alternative approach against B. abortus infection via experiments using in vitro and in vivo tests; here, we explored the effects of a synthetic SIRT1 and SIRT2 inhibitor, cambinol, in regard to the ability of B. abortus to adhere, invade and grow intracellularly in a murine macrophage cell line while also examining bacterial dissemination and immunoregulation in a mouse model for the purpose of finding alternative treatment against animal brucellosis.