In many cancers, HERV LTRs have been observed to drive cancer-specific or tissue-specific transcripts, including oncogenes such as ADAM metallopeptidase with thrombospondin type 1 motif 5 (ADAMTS5), which is specifically controlled by the LTR mammalian LTR transposon 1J2 (MLT1J2) in thyroid tissues [43]. This evidence concerns the gene ADAMTS5 and cancer.