Sodium thiosulfates’ multifactorial mechanistic roles include its protective effects on the pathologic roles of oxidative redox stress, inflammation/neuroinflammation, the chelation of excess calcium associated with glutamate excitotoxicity, and iron due to hemorrhages and cerebral microbleeds; its possible restorative neurovascular unit effects regarding the improvement of the brain endothelial cell and endothelial nitric oxide synthase enzyme; its essential cofactor tetrahydrobiopterin with restoration of nitric oxide production and bioavailability. Here, NOS3 is linked to cerebral microbleeds.