Additionally, CTX disrupts ClC-3 by interacting with a complex protein composed of matrix metalloproteinase-2 (MMP-2), membrane type 1 matrix metalloprotease (MT1-MMP), and the tissue inhibitor of matrix metalloproteinase-2 (TIMP-2) on the surface of glioma cell membranes. This evidence concerns the gene MMP2 and central nervous system cancer.