EGFR and female reproductive system neoplasm: This model is also a precious system for spontaneously developing ovarian cancer, which has similar pathological, histological, and molecular features to humans and shares common molecular alterations such as mutations of p53, BRCA, VEGF, and EGFR [39,45], indicating that hen models could be an excellent value for evaluating the chemopreventive role of dietary compounds in human gynecological tumors.