HMOX1 and neoplasm: Daily curcumin intake significantly reduced tumor incidence, growth, and count, with effects mediated through multiple mechanisms, including the inhibition of NF-κB signaling, the activation of antioxidant pathways (Nrf2/HO-1), the suppression of PI3K/Akt/mTOR signaling, the reduction in inflammatory cytokines, and the modulation of steroid receptors.