By analyzing the impact of prolonged curcumin supplementation on tumor incidence, growth, and molecular signaling pathways (NF-κB, mTOR, p70S6K1, 4E-BP1, Nrf2/HO1), this research aims to uncover curcumin’s mechanisms of action and assess its viability as a dietary intervention for LM prevention. Here, NFKB1 is linked to lymphangioma.