TGFB1 and neoplasm: The curcumin-induced suppression of TGF-β1 activation, which is induced by inflammatory cytokines, may be one of the critical mechanisms of chemopreventive and therapeutic effects as TGF-β signaling has been reported to function as a tumor suppressor and to play a critical role in preventing carcinogenesis in normal epithelial cells by inducing cell cycle arrest, apoptosis, and the prevention of cell immortalization [59].