In the study by Meng et al., the SUVmax of primary RCC lesions in [68Ga]Ga-PSMA-11 PET/CT correlated with high hypoxia-inducible factor 2 alpha (HIF-2α) expression, which could potentially be helpful in predicting the response to treatment with HIF-2α antagonists [58]. This evidence concerns the gene EPAS1 and renal cell carcinoma.