Key signaling molecules, including transforming growth factor beta (TGFβ) related to SRC, interleukin 1 (IL-1) associated with FOS, CXC chemokine (CXCL2), and vascular endothelial growth factor (VEGF), were highlighted due to their critical roles in tumor initiation, progression, and deterioration. This evidence concerns the gene TGFB1 and neoplasm.