In an experiment of amyloid-beta (Aβ)-induced AD PC12 cells, salidroside (12.5, 25, 50, 100, 200 μmol/L) enhanced the viability of cells in a dose-dependent manner, decreased the levels of ROS and MDA, increased the levels of SOD, and up-regulated the phosphorylation levels of ERK1/2 and Akt. This evidence concerns the gene SOD1 and Alzheimer disease.