Salidroside (0.5, 1.0, and 2.0 mg/mL) was co-cultured with human hepatocellular carcinoma HepG2 cells for 24 h, 48 h, and 72 h, and the results showed that salidroside could dose-dependently reduce the adherence of HepG2 cells to the basement membrane, and down-regulate the expression of MMP-1, suggesting that salidroside could inhibit the infiltration and metastasis of tumor cells by regulating MMP-1 expression [170]. Here, MMP1 is linked to hepatocellular carcinoma.