It was found that the level of BDNF protein in the hippocampus was significantly up-regulated, and the levels of NF-κB, NLRP3, and IL-1β were significantly decreased, suggesting that salidroside may ameliorate depression by inhibiting the NF-κB/NLRP3 signaling pathway. The gene discussed is NFKB1; the disease is major depressive disorder.