CASP3 and acute respiratory distress syndrome: Meanwhile, the capsaicin + Nerelimomab group exhibited a significantly increased Bcl-2/Bax ratio (p < 0.01) and decreased cleaved caspase 3 expression (p < 0.05), suggesting that Nerelimomab inhibits apoptosis in capsaicin-induced ALI by modulating the TNF signaling pathway.