Central to its pathogenesis is the activation of the NOD-like receptor pyrin domain-containing 3 (NLRP3) inflammasome, which contributes to the catastrophic cytokine storm leading to acute respiratory distress syndrome (ARDS) and increased mortality, especially in patients with comorbidities, like diabetes and obesity [84,85,86,87]. This evidence concerns the gene NLRP3 and acute respiratory distress syndrome.