Endogenously, the channel may be activated by reactive oxygen species in metastatic colorectal carcinoma cells [8] or breast and lung cancer [28], and even in tumours with a low TRPA1 expression, activating or blocking the channel may have therapeutic potential, as was proved for glioblastoma [10], osteosarcoma [7] and pancreatic cancer [5]. Here, TRPA1 is linked to familial pancreatic carcinoma.