Cancers in which TRPA1 is significantly underexpressed, and therefore may act as a tumor suppressor, are bladder urothelial carcinoma (BLCA), colon adenocarcinoma (COAD), kidney chromophobe (KICH), glioblastoma multiforme (GBM) and rectum adenocarcinoma (READ). The gene discussed is TRPA1; the disease is rectum adenocarcinoma.