Compared to single-specificity tracers, the dual-receptor targeting strategy enhances tumor targeting efficiency in NCI-H727 tumors and prolongs the tumor retention time, indicating that [68Ga]Ga-TATE-46 is a promising non-invasive tracer for detecting tumors that simultaneously express SSTR2and FAP (e.g., nasopharyngeal carcinoma, thyroid carcinoma and breast cancer), with good potential for clinical translation. The gene discussed is FAP; the disease is breast carcinoma.