Iezzi [37] used (in an ovarian tumor cell line) the combination of Akt pathway and c-MET inhibitors (PF-05212384 and crizotinib, respectively), showing a synergistic effect between both, corroborating that they act upon different pathways (Akt/c-MET), which explains the cell cycle arrest but not the migration inhibition of PKI-587 in the T98G cell line. This evidence concerns the gene AKT1 and ovarian neoplasm.