Besides CACNA2D3, the human CACNA2D1 gene has also recently been associated with neurodevelopmental disorders, including intellectual disability, ASD, and developmental and epileptic encephalopathy (DEE) [22,23,24], illustrating the essential role and unique functions of α2δ-1 along with other α2δ proteins in the proper development of neuronal networks. The gene discussed is CACNA2D3; the disease is developmental and epileptic encephalopathy.