Basically, Th17 cell differentiation, Th1 and Th2 cell differentiation, inflammatory bowel disease, PD-L1 expression and PD-1 checkpoint pathway in cancer, the T cell receptor signaling pathway, Chagas disease, the C-type lectin receptor signaling pathway, Osteoclast differentiation, the IL-17 signaling pathway, the AGE-RAGE signaling pathway, and the top 10 pathways that occur in diabetic complications are shown (Figure 7). Here, CD274 is linked to Chagas disease.