In addition to correctors and potentiators, CFTR inhibitors like CFTRinh-172 have been studied for their potential to regulate CFTR activity, particularly useful in conditions where CFTR function needs to be downregulated (such as secretory diarrhea caused by cholera toxins, where CFTR hyperactivation leads to excessive fluid and chloride secretion) [75]. This evidence concerns the gene CFTR and vibrio infectious disease.