Isoquercitrin also enhanced the levels of immunogenic cell death (ICD) markers, such as calreticulin (CALR), adenosine triphosphate (ATP), high mobility group box 1 (HMGB1), heatshockprotein70 (HSP70), and heatshockprotein90 (HSP90), suggesting its potential role in immune system activation against cancer cells. This evidence concerns the gene HMGB1 and cancer.