However, there were exceptions in case of some rare prophylactic NSAID indications for heterotopic ossification, which were excluded if there was severe renal insufficiency and/or if there were concomitant drug risks with ACE inhibitors or sartans, and particularly always avoiding so-called “triple whammy” with add-on diuretics, furthermore [41]. The gene discussed is ACE; the disease is Renal insufficiency.