JAK2 and cancer: In addition, cucurbitacin D (CucD) also deserves attention on account of its antiproliferative activity in a variety of cancers, including human adult T-cell leukemia and breast, cervical, prostate, gastric, lung, and liver cancers, by modulating several pathways involved in cancer cell proliferation, such as the PI3K/AKT/mTOR, MAPKs, JAK2/STAT3, ROS/p38, NF-kappa B, and EGFR pathways, which are linked to ZNF217 expression [14,15,16,17,18].