Depending on the phase of the infection, it has been reported that a high titer of IgM is indicative of an early or acute infection and a high titer of IgG is found in a chronic or latent infection, while both IgM and IgG simultaneously elevated suggests the presence of an active infection, whether it is an acute, a reactivated infection, or a reinfection [12]. Here, CD40LG is linked to disease arising from reactivation of latent virus.