AKT1 and obesity due to melanocortin 4 receptor deficiency: UMA enhances the growth of Akkermansia muciniphila, inversely correlated with obesity, and improves dysregulation of phosphatidylinositol 3-kinase–protein kinase B (PI3K-Akt) in prostate cancer patients [26,133,139] UM0 is characterized by a low abundance of butyrate-producing microbial species and a high number of Enterobacteriaceae [10].