Evaluation of the effects of the K. crenata extract on the activity of aortic MMP2, which constituted the third aim of our study, showed that the activity of the 72 kDA isoform of the metalloendopeptidase was reduced significantly in rats treated with losartan (HTN 3 group) or with K. crenata extract plus losartan (HTN 4 group), but not with K. crenata alone (HTN 2). The gene discussed is MMP2; the disease is hypertensive disorder.