MMP2 and hypertensive disorder: Zymography of MMP2 in aortic tissues revealed that the activities of the 72 kDa isoform were reduced significantly in hypertensive animals treated with losartan (group HTN 3; p < 0.01) or with a combination of K. crenata extract and losartan (group HTN 4; p < 0.05) (Figure 5).