Rhein—another anthraquinone derivative—was capable of inducing apoptosis and inhibiting the EGFR and STAT3 pathways in tumor remnants, in combination with EGFR inhibitors, with clear suppression of the Bcl-2 level and an increase in the level of Bax [84], and, additionally, inhibiting the expression of β-catenin [85], which was proven in a mice HepG2 xenograft model, together with the inhibition of tumor growth. This evidence concerns the gene EGFR and neoplasm.