SF has been shown to produce a dose-dependent reduction in glucose production in rat hepatoma cells, which correlated with increased Nrf2 activity and the downregulation of gluconeogenetic enzymes (phospho-renolpyruvate carboxykinase 1, fructose-1,6-bisphosphatase 1, and glucose-6-phosphatase catalytic subunit) [87]. The gene discussed is NFE2L2; the disease is hepatocellular carcinoma.