NFE2L2 and cancer: Based primarily on their detoxification capacity (primarily via the Keap1-Nrf2 pathway) and their anti-inflammatory activities, they have broad applicability to address a variety of disease states including cancer prevention and therapy [18,19,20], neurodevelopmental and neurodegenerative conditions [3], diabetes [21], ophthalmic conditions [22], kidney disease [23], diseases of the liver [24], intestinal inflammation and GI disorders [25,26], and cardiovascular disease [27].