On the contrary, hepatic ORM2 levels markedly decreased in obese murine models and patients with MASLD and was observed also to be essential to maintain systemic lipid homeostasis [51] A similar trend was also observed in our dataset, where the HFD mice showed an increase in SAA1 and a decrease in ORM2 gene expression. This evidence concerns the gene SAA1 and metabolic dysfunction-associated steatotic liver disease.