On the contrary, hepatic ORM2 levels markedly decreased in obese murine models and patients with MASLD and was observed also to be essential to maintain systemic lipid homeostasis [51] A similar trend was also observed in our dataset, where the HFD mice showed an increase in SAA1 and a decrease in ORM2 gene expression. The gene discussed is ORM2; the disease is metabolic dysfunction-associated steatotic liver disease.